KDM4B

Lysine-specific demethylase 4B is an enzyme that in humans is encoded by the KDM4B gene.^[5][6][7] KDM4B belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

KDM4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LXL, 4UC4
Identifiers
Aliases	KDM4B, JMJD2B, TDRD14B, lysine demethylase 4B, MRD65
External IDs	OMIM: 609765; MGI: 2442355; HomoloGene: 27773; GeneCards: KDM4B; OMA:KDM4B - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 4,969,113 bp[1] End 5,153,598 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 D Start 56,633,062 bp[2] End 56,709,870 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in dorsal motor nucleus of vagus nerve corpus epididymis blood caput epididymis inferior olivary nucleus sural nerve parotid gland tendon of biceps brachii nipple Skeletal muscle tissue of biceps brachii Top expressed in Rostral migratory stream lip neural layer of retina superior frontal gyrus otic vesicle primary visual cortex external carotid artery dentate gyrus of hippocampal formation granule cell granulocyte muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity dioxygenase activity metal ion binding histone demethylase activity histone H3-methyl-lysine-36 demethylase activity histone H3-methyl-lysine-9 demethylase activity DNA-binding transcription repressor activity, RNA polymerase II-specific chromatin binding methylated histone binding Cellular component nucleoplasm nucleus histone methyltransferase complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated histone H3-K36 demethylation histone H3-K9 demethylation chromatin organization negative regulation of transcription by RNA polymerase II chromatin remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23030 193796 Ensembl ENSG00000127663 ENSMUSG00000024201 UniProt O94953 Q91VY5 RefSeq (mRNA) NM_015015 NM_001370093 NM_001370094 NM_172132 NM_001357909 RefSeq (protein) NP_055830 NP_001357022 NP_001357023 NP_742144 NP_001344838 Location (UCSC) Chr 19: 4.97 – 5.15 Mb Chr 17: 56.63 – 56.71 Mb PubMed search [3] [4]
Wikidata
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