KDM5D

Lysine-specific demethylase 5D is an enzyme that in humans is encoded by the KDM5D gene.^[5][6][7] KDM5D belongs to the alpha-ketoglutarate-dependent hydroxylases superfamily.

KDM5D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E6R, 2YQE
Identifiers
Aliases	KDM5D, HY, HYA, JARID1D, SMCY, lysine demethylase 5D
External IDs	OMIM: 426000; MGI: 99780; HomoloGene: 55838; GeneCards: KDM5D; OMA:KDM5D - orthologs
Gene location (Human) Chr. Y chromosome (human)[1] Band Yq11.223 Start 19,703,865 bp[1] End 19,744,939 bp[1]
Gene location (Mouse) Chr. Y chromosome (mouse)[2] Band Y|Ypter Start 897,788 bp[2] End 956,786 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart rectum right lung prostate skin of thigh mucosa of transverse colon urethra trabecular bone gonad Brodmann area 9 Top expressed in tail of embryo left lung lobe internal carotid artery external carotid artery female urethra granulocyte male urethra vas deferens triceps brachii muscle epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone H3-methyl-lysine-4 demethylase activity DNA binding oxidoreductase activity dioxygenase activity metal ion binding histone demethylase activity androgen receptor binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific chromatin binding histone H3-tri/di/monomethyl-lysine-4 demethylase activity methylated histone binding Cellular component nucleus nucleoplasm fibrillar center cellular component histone methyltransferase complex Biological process histone H3-K4 demethylation T cell antigen processing and presentation transcription, DNA-templated regulation of transcription, DNA-templated regulation of androgen receptor signaling pathway chromatin organization regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II histone H3-K4 demethylation, trimethyl-H3-K4-specific chromatin remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8284 20592 Ensembl ENSG00000012817 ENSMUSG00000056673 UniProt Q9BY66 Q62240 RefSeq (mRNA) NM_001146705 NM_001146706 NM_004653 NM_011419 RefSeq (protein) NP_001140177 NP_001140178 NP_004644 NP_035549 Location (UCSC) Chr Y: 19.7 – 19.74 Mb Chr Y: 0.9 – 0.96 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient.^[7]