KDM8

Lysine demethylase 8 is a protein that in humans is encoded by the KDM8 gene.^[5]

KDM8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3UYJ, 4AAP, 4GAZ, 4GJY, 4GJZ, 4QU1
Identifiers
Aliases	KDM8, JMJD5, lysine demethylase 8
External IDs	OMIM: 611917; MGI: 1924285; HomoloGene: 49791; GeneCards: KDM8; OMA:KDM8 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 27,203,508 bp[1] End 27,221,768 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 125,043,848 bp[2] End 125,061,441 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver duodenum testicle gonad granulocyte apex of heart epithelium of colon body of pancreas prefrontal cortex mucosa of transverse colon Top expressed in retinal pigment epithelium primitive streak cumulus cell neural layer of retina embryo morula secondary oocyte ventricular zone triceps brachii muscle Rostral migratory stream More reference expression data BioGPS n/a
Gene ontology Molecular function dioxygenase activity chromatin binding oxidoreductase activity metal ion binding histone H3-methyl-lysine-36 demethylase activity histone demethylase activity protein binding peptidase activity hydrolase activity aminopeptidase activity endopeptidase activity 2-oxoglutarate-dependent dioxygenase activity methylated histone binding Cellular component nucleus nucleoplasm cytosol chromosome Biological process regulation of transcription, DNA-templated cell cycle G2/M transition of mitotic cell cycle positive regulation of transcription, DNA-templated histone H3-K36 demethylation transcription, DNA-templated proteolysis chromatin organization protein destabilization circadian regulation of gene expression negative regulation of transcription, DNA-templated rhythmic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79831 77035 Ensembl ENSG00000155666 ENSMUSG00000030752 UniProt Q8N371 Q9CXT6 RefSeq (mRNA) NM_001145348 NM_024773 NM_029842 RefSeq (protein) NP_001138820 NP_079049 NP_084118 Location (UCSC) Chr 16: 27.2 – 27.22 Mb Chr 7: 125.04 – 125.06 Mb PubMed search [3] [4]
Wikidata
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Function

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.