KIAA1279

KIF1-binding protein, also known as Kinesin binding protein(KBP), is a protein that in humans is encoded by the KIAA1279 gene.^[5] The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator.^[6] Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis.^[7] Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis,^[8] and hence it can be therapeutically used to control Kif15 upregulated cancer cells.

KIFBP
Identifiers
Aliases	KIFBP, KBP, KIAA1279, TTC20, KIF1 binding protein, kinesin family binding protein, KIF1BP
External IDs	OMIM: 609367; MGI: 1919570; HomoloGene: 9223; GeneCards: KIFBP; OMA:KIFBP - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.1 Start 68,988,803 bp[1] End 69,043,544 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 62,374,405 bp[2] End 62,414,236 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole ventricular zone secondary oocyte paraflocculus of cerebellum right ventricle middle frontal gyrus prefrontal cortex gonad ganglionic eminence Brodmann area 9 Top expressed in temporal lobe amygdala olfactory epithelium Region I of hippocampus proper prefrontal cortex anterior horn of spinal cord hippocampus proper facial motor nucleus nucleus accumbens Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding kinesin binding Cellular component cytoplasm cytoskeleton mitochondrion Biological process multicellular organism development cell differentiation mitochondrial transport nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26128 72320 Ensembl ENSG00000198954 ENSMUSG00000036955 UniProt Q96EK5 Q6ZPU9 RefSeq (mRNA) NM_015634 NM_028197 RefSeq (protein) NP_056449 NP_082473 Location (UCSC) Chr 10: 68.99 – 69.04 Mb Chr 10: 62.37 – 62.41 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

Defects may be associated with Goldberg–Shprintzen syndrome (OMIM 609460).

Interactions

KIAA1279 has been shown to interact with Retinal G protein coupled receptor^[9] and Dipeptidase 1.^[9]