KIF14

Kinesin-like protein KIF14 is a protein that in humans is encoded by the KIF14 gene.^[5][6]

KIF14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OZQ
Identifiers
Aliases	KIF14, MKS12, kinesin family member 14, MCPH20
External IDs	OMIM: 611279; MGI: 1098226; HomoloGene: 8916; GeneCards: KIF14; OMA:KIF14 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 200,551,497 bp[1] End 200,620,751 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 E4|1 59.8 cM Start 136,394,081 bp[2] End 136,459,249 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte trabecular bone gonad ventricular zone buccal mucosa cell testicle embryo bone marrow thymus ganglionic eminence Top expressed in zygote tail of embryo genital tubercle secondary oocyte spermatocyte ventricular zone spermatid yolk sac blastocyst embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function tubulin binding nucleotide binding protein kinase binding plus-end-directed microtubule motor activity PDZ domain binding microtubule motor activity microtubule binding ATP binding protein binding ATPase activity Cellular component spindle cytoplasm kinesin complex nucleus membrane midbody microtubule plasma membrane spindle midzone cytoskeleton cytosol Flemming body Biological process negative regulation of integrin activation cerebral cortex development negative regulation of apoptotic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process regulation of neuron apoptotic process hippocampus development regulation of cell growth cell division substrate adhesion-dependent cell spreading regulation of G1/S transition of mitotic cell cycle cell proliferation in forebrain regulation of G2/M transition of mitotic cell cycle cerebellar granular layer structural organization olfactory bulb development microtubule depolymerization proteasome-mediated ubiquitin-dependent protein catabolic process cerebellar Purkinje cell layer structural organization regulation of myelination positive regulation of cell population proliferation regulation of Rap protein signal transduction cerebellar cortex development positive regulation of cytokinesis negative regulation of neuron apoptotic process establishment of protein localization regulation of cell migration mitotic metaphase plate congression regulation of cell maturation microtubule-based movement activation of protein kinase activity regulation of cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9928 381293 Ensembl ENSG00000118193 ENSMUSG00000041498 UniProt Q15058 L0N7N1 RefSeq (mRNA) NM_001305792 NM_014875 NM_001081258 NM_001287179 RefSeq (protein) NP_001292721 NP_055690 NP_001274108 Location (UCSC) Chr 1: 200.55 – 200.62 Mb Chr 1: 136.39 – 136.46 Mb PubMed search [3] [4]
Wikidata
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