KIF15

Kinesin family member 15 is a protein that in humans is encoded by the KIF15 gene.^[5]

KIF15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BN2
Identifiers
Aliases	KIF15, HKLP2, KNSL7, NY-BR-62, kinesin family member 15, KLP2
External IDs	OMIM: 617569; MGI: 1098258; HomoloGene: 23210; GeneCards: KIF15; OMA:KIF15 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 44,761,721 bp[1] End 44,873,376 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F4 Start 122,780,111 bp[2] End 122,847,798 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence left testis right testis testicle gonad bone marrow mucosa of transverse colon bone marrow cell endometrium Top expressed in tail of embryo genital tubercle spermatocyte ventricular zone spermatid embryo yolk sac embryo blastocyst morula More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding microtubule motor activity nucleotide binding microtubule binding ATPase activity cytoskeletal motor activity ATP binding protein binding Cellular component cytoplasm cytosol centrosome membrane spindle plus-end kinesin complex microtubule cytoskeleton kinesin complex Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II microtubule-based movement cell population proliferation retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56992 209737 Ensembl ENSG00000280610 ENSG00000163808 ENSMUSG00000036768 UniProt Q9NS87 Q6P9L6 RefSeq (mRNA) NM_020242 NM_010620 RefSeq (protein) NP_064627 NP_034750 Location (UCSC) Chr 3: 44.76 – 44.87 Mb Chr 9: 122.78 – 122.85 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a motor protein that is part of the kinesin superfamily. KIF15 maintains half spindle separation by opposing forces generated by other motor proteins. KIF15 co-localizes with microtubules and actin filaments in both dividing cells and in postmitotic neurons.^[5]

Function

KIF15 (also known as Kinesin-12 and HKLP2) is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth.^[6] KIF15 maintains bipolar microtubule spindle apparatus in dividing cells and shares redundant functions with KIF11.^[7] KIF15 is thought to promote spindle assembly by cross-linking and sliding along microtubules creating a separation between centrosomes. The microtubule localization of Kif15 is being regulated by Kinesin binding protein (KBP).^[8] HeLa cells depleted of KIF11, with reduced microtubule dynamics, are able to form bipolar spindles from acentrosomal asters in a KIF15 dependent manner.^[9][10] Hence, inhibition of KIF15 function will be a vital therapeutic approach in cancer chemotherapy.^[11] Since KIF11 and KIF15 are functionally redundant, drugs targeting both the proteins will be more potent.^[8]

Function in neurons

KIF15 restricts the movement of short microtubules into growing axons by generating forces on microtubules which counteract those generated by cytoplasmic dynein.^[12][13] KIF15, together with KIF23 become enriched in dendrites as neurons mature to promote the transport of minus-end distal microtubules into nascent dendrites.^[12]

Interactions

KIF15 has been shown to interact with TPX2. Both these dimers cooperate to slide along microtubules and maintain bipolar spindles.^[14][15]