KIF17

Kinesin-like protein KIF17 is a protein that in humans is encoded by the KIF17 gene.^[5][6] KIF17 and its close relative, C. elegans OSM-3,^[7] are members of the kinesin-2 family of plus-end directed microtubule-based motor proteins.^[8] In contrast to heterotrimeric kinesin-2 motors,^[9] however, KIF17 and OSM-3 form distinct homodimeric complexes.^[10] Homodimeric kinesin-2 has been implicated in the transport of NMDA receptors along dendrites for delivery to the dendritic membrane,^[5] whereas both heterotrimeric and homodimeric kinesin-2 motors function cooperatively in anterograde intraflagellar transport (IFT) and cilium biogenesis.^[11][12]

KIF17
Identifiers
Aliases	KIF17, Kif17, 5930435E01Rik, AW492270, Kif17b, mKIAA1405, KIF3X, KLP-2, OSM-3, kinesin family member 17
External IDs	OMIM: 605037; MGI: 1098229; HomoloGene: 5883; GeneCards: KIF17; OMA:KIF17 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 20,664,014 bp[1] End 20,718,017 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 137,977,746 bp[2] End 138,029,278 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis right adrenal cortex left adrenal gland spleen left adrenal cortex right frontal lobe prefrontal cortex testicle apex of heart Top expressed in primary oocyte zygote seminiferous tubule secondary oocyte spermatid superior frontal gyrus visual cortex primary visual cortex lumbar subsegment of spinal cord dorsal striatum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding microtubule motor activity microtubule binding plus-end-directed microtubule motor activity ATP binding ATPase activity Cellular component intraciliary transport particle B cytoplasm ciliary basal body cytosol kinesin complex microtubule cytoskeleton photoreceptor connecting cilium periciliary membrane compartment axoneme microtubule cytoskeleton cell projection cilium dendrite cytoplasm neuron projection Biological process microtubule-based movement cell projection organization microtubule-based process protein transport protein-containing complex localization vesicle-mediated transport neurogenesis intraciliary transport involved in cilium assembly anterograde dendritic transport of neurotransmitter receptor complex Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57576 16559 Ensembl ENSG00000117245 ENSMUSG00000028758 UniProt Q9P2E2 Q99PW8 RefSeq (mRNA) NM_001122819 NM_001287212 NM_020816 NM_001190978 NM_010623 RefSeq (protein) NP_001116291 NP_001274141 NP_065867 NP_001177907 NP_034753 Location (UCSC) Chr 1: 20.66 – 20.72 Mb Chr 4: 137.98 – 138.03 Mb PubMed search [3] [4]
Wikidata
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