KIF18A

Kinesin family member KIF18A is a human protein encoded by the KIF18A gene.^[5][6] It is part of the kinesin family of motor proteins.

KIF18A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LRE
Identifiers
Aliases	KIF18A, MS-PPP1R99, kinesin family member 18A
External IDs	OMIM: 611271; MGI: 2446977; HomoloGene: 41820; GeneCards: KIF18A; OMA:KIF18A - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p14.1 Start 28,020,619 bp[1] End 28,108,156 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E3 Start 109,111,083 bp[2] End 109,172,092 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone gonad testicle secondary oocyte ganglionic eminence sperm left testis right testis stromal cell of endometrium bone marrow Top expressed in zygote secondary oocyte primary oocyte spermatid fetal liver hematopoietic progenitor cell ventricular zone genital tubercle spermatocyte epiblast tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding microtubule motor activity tubulin-dependent ATPase activity microtubule binding microtubule plus-end binding protein binding actin binding plus-end-directed microtubule motor activity ATP binding ATPase activity Cellular component cytoplasm cytosol cell projection kinetochore microtubule kinesin complex ruffle microtubule cytoskeleton microtubule organizing center mitotic spindle midzone caveola microtubule cytoskeleton nucleus kinetochore mitotic spindle astral microtubule Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II male meiotic nuclear division regulation of microtubule cytoskeleton organization microtubule-based movement seminiferous tubule development protein transport microtubule depolymerization mitotic metaphase plate congression retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular response to estradiol stimulus mitotic sister chromatid segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81930 228421 Ensembl ENSG00000121621 ENSMUSG00000027115 UniProt Q8NI77 Q91WD7 RefSeq (mRNA) NM_031217 NM_139303 RefSeq (protein) NP_112494 NP_647464 Location (UCSC) Chr 11: 28.02 – 28.11 Mb Chr 2: 109.11 – 109.17 Mb PubMed search [3] [4]
Wikidata
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Function

KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted during anaphase.^[7]

KIF18a(-/-) knockout in mice results in complete sterility in males, but not females, due to abnormal development of the seminiferous tubules.^[8] The mice were otherwise normal, suggesting KIF18a is not essential for cell divisions in non-germ cells.

Therapeutic Target

KIF18A has been considered as a cancer target because it is overexpressed in many cancer types and mouse studies suggest it is dispensable in somatic cells.^[9] As such, small molecule inhibitors of KIF18A have been developed to block its activity. ^[9]