KIF22

Kinesin-like protein KIF22 is a protein that in humans is encoded by the KIF22 gene.^[5][6][7]

KIF22
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EDU, 3BFN
Identifiers
Aliases	KIF22, A-328A3.2, KID, KNSL4, OBP, OBP-1, OBP-2, SEMDJL2, kinesin family member 22
External IDs	OMIM: 603213; MGI: 109233; HomoloGene: 32011; GeneCards: KIF22; OMA:KIF22 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 29,790,727 bp[1] End 29,805,385 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F3|7 69.29 cM Start 126,626,901 bp[2] End 126,641,643 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence right lobe of thyroid gland left lobe of thyroid gland apex of heart mucosa of transverse colon gonad granulocyte rectum right testis Top expressed in human fetus Ileal epithelium fetal liver hematopoietic progenitor cell Paneth cell medial ganglionic eminence tibiofemoral joint primary oocyte primitive streak ureter internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding microtubule binding ATPase activity protein binding ATP binding microtubule motor activity Cellular component kinesin complex spindle chromatin mitotic spindle microtubule cytoskeleton kinetochore nucleus cytoplasm cytosol nuclear speck Biological process metaphase plate congression antigen processing and presentation of exogenous peptide antigen via MHC class II sister chromatid cohesion microtubule-based movement mitotic metaphase plate congression DNA repair retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3835 110033 Ensembl ENSG00000079616 ENSMUSG00000030677 UniProt Q14807 Q3V300 RefSeq (mRNA) NM_001256269 NM_001256270 NM_007317 NM_145588 RefSeq (protein) NP_001243198 NP_001243199 NP_015556 NP_663563 NP_001390552 Location (UCSC) Chr 16: 29.79 – 29.81 Mb Chr 7: 126.63 – 126.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests an essential role in metaphase chromosome alignment and maintenance.^[7]

Interactions

KIF22 has been shown to interact with SIAH1.^[8]

Clinical relevance

Mutations in this gene have been shown to cause developmental disorders such as Spondyloepimetaphyseal dysplasia with joint laxity.^[9]