KIF25

Kinesin family member 25 (KIF25), also known as kinesin-14, is a human protein encoded by the KIF25 gene. It is part of the kinesin family of motor proteins.

KIF25
Identifiers
Aliases	KIF25, KNSL3, kinesin family member 25
External IDs	OMIM: 603815; HomoloGene: 49939; GeneCards: KIF25; OMA:KIF25 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q27 Start 167,996,241 bp[1] End 168,045,091 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad buccal mucosa cell testicle right hemisphere of cerebellum apex of heart C1 segment abdominal fat right frontal lobe putamen dorsolateral prefrontal cortex n/a More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding microtubule motor activity nucleotide binding ATPase activity ATP binding minus-end-directed microtubule motor activity Cellular component cytoplasm microtubule cytoskeleton kinesin complex centrosome microtubule organizing center Biological process microtubule-based movement negative regulation of autophagy organelle organization mitotic sister chromatid segregation negative regulation of mitotic centrosome separation protein homotetramerization establishment of spindle orientation nucleus localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3834 n/a Ensembl ENSG00000125337 n/a UniProt Q9UIL4 n/a RefSeq (mRNA) NM_005355 NM_030615 n/a RefSeq (protein) NP_005346 NP_085118 n/a Location (UCSC) Chr 6: 168 – 168.05 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

KIF25 is a minus-end directed microtubule motor protein, and its activity delays the separation of chromosomes during mitosis.^[3]