KIF2C

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.^[5][6]

KIF2C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HEH, 4UBF, 4Y05
Identifiers
Aliases	KIF2C, CT139, KNSL6, MCAK, kinesin family member 2C
External IDs	OMIM: 604538; MGI: 1921054; HomoloGene: 21355; GeneCards: KIF2C; OMA:KIF2C - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.1 Start 44,739,818 bp[1] End 44,767,767 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D1|4 53.42 cM Start 117,016,836 bp[2] End 117,039,836 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone right testis left testis sperm embryo ganglionic eminence gonad testicle bone marrow Top expressed in otic placode seminiferous tubule otic vesicle primary oocyte saccule primitive streak maxillary prominence spermatid endothelial cell of lymphatic vessel mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding microtubule binding microtubule plus-end binding centromeric DNA binding ATPase activity protein binding ATP binding microtubule motor activity Cellular component cytoplasm membrane kinesin complex microtubule cytoskeleton chromosome microtubule plus-end cytoplasmic microtubule chromosome, centromeric region cytoskeleton microtubule nucleus kinetochore nucleoplasm centrosome cytosol Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II establishment or maintenance of microtubule cytoskeleton polarity chromosome segregation cell division regulation of chromosome segregation microtubule-based movement cell cycle microtubule depolymerization mitotic metaphase plate congression cell population proliferation retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum sister chromatid cohesion metaphase plate congression attachment of mitotic spindle microtubules to kinetochore mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11004 73804 Ensembl ENSG00000142945 ENSMUSG00000028678 UniProt Q99661 Q922S8 RefSeq (mRNA) NM_001297655 NM_001297656 NM_001297657 NM_006845 NM_001290662 NM_134471 RefSeq (protein) NP_001284584 NP_001284585 NP_001284586 NP_006836 NP_001277591 NP_608301 Location (UCSC) Chr 1: 44.74 – 44.77 Mb Chr 4: 117.02 – 117.04 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of kinesin-like protein family, and contains common ATPase site structures such as the P-loop, Switch 1, and Switch 2.^[7] Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.^[6]

A ribbon and surface diagram of the KIF2C motor domain.^[8] The kinesin structure is pseudo-colored to highlight the ATPase site with a bound nucleotide. The figure then presents KIF2C binding to the tubulin dimer and finally visualizes a KIF2C motor head in the context of the microtubule filament.