KIF3A

Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene.^[5][6]

KIF3A
Identifiers
Aliases	KIF3A, FLA10, KLP-20, kinesin family member 3A
External IDs	OMIM: 604683; MGI: 107689; HomoloGene: 38266; GeneCards: KIF3A; OMA:KIF3A - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 132,692,628 bp[1] End 132,737,638 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.3|11 31.97 cM Start 53,458,206 bp[2] End 53,492,794 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell middle temporal gyrus secondary oocyte Pons buccal mucosa cell entorhinal cortex postcentral gyrus superior vestibular nucleus sural nerve Top expressed in ventromedial nucleus genital tubercle anterior amygdaloid area lateral septal nucleus mammillary body dorsomedial hypothalamic nucleus lens paraventricular nucleus of hypothalamus supraoptic nucleus medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding microtubule motor activity spectrin binding microtubule binding protein binding plus-end-directed microtubule motor activity ATP binding ATPase activity protein phosphatase binding Cellular component cytoplasm cytosol centrosome cell projection microtubule cytoskeleton kinesin II complex ciliary tip spindle microtubule extracellular exosome cytoskeleton microtubule centriole cilium kinesin complex axon cytoplasm Biological process plus-end-directed vesicle transport along microtubule antigen processing and presentation of exogenous peptide antigen via MHC class II organelle organization microtubule-based movement cell projection organization retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum neurogenesis centriole-centriole cohesion microtubule anchoring at centrosome intraciliary transport involved in cilium assembly cilium assembly axon guidance anterograde axonal transport protein transport protein localization to cell junction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11127 16568 Ensembl ENSG00000131437 ENSMUSG00000018395 UniProt Q9Y496 P28741 RefSeq (mRNA) NM_001300791 NM_001300792 NM_007054 NM_001290805 NM_001290806 NM_008443 RefSeq (protein) NP_001287720 NP_001287721 NP_008985 NP_001277734 NP_001277735 NP_032469 Location (UCSC) Chr 5: 132.69 – 132.74 Mb Chr 11: 53.46 – 53.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification.^[7] This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein (KAP3), and it transports protein complexes, nucleic acids and organelles towards the "plus" ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intraflagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips.^[8] This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry.^[9]

Interactions

KIF3A has been shown to interact with MAP3K10.^[10]