KIRREL2

Kin of IRRE-like protein 2, also known as NEPH3, is a protein that in humans is encoded by the KIRREL2 gene.^[5][6][7] It is primarily expressed in β cells of the pancreatic islets.^[5]

KIRREL2
Identifiers
Aliases	KIRREL2, FILTRIN, NEPH3, NLG1, kin of IRRE like 2 (Drosophila), kirre like nephrin family adhesion molecule 2
External IDs	OMIM: 607762; MGI: 2442334; HomoloGene: 35249; GeneCards: KIRREL2; OMA:KIRREL2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 35,855,861 bp[1] End 35,867,136 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 30,146,959 bp[2] End 30,157,115 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans ventricular zone ganglionic eminence retinal pigment epithelium prefrontal cortex external globus pallidus lymph node Brodmann area 9 cingulate gyrus Top expressed in primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell white matter of cerebellum respiratory epithelium striatum of neuraxis islet of Langerhans spinal cord nasal epithelium rhombic lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding Cellular component integral component of membrane slit diaphragm membrane plasma membrane cell-cell junction Biological process negative regulation of protein phosphorylation cell adhesion cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84063 243911 Ensembl ENSG00000126259 ENSMUSG00000036915 UniProt Q6UWL6 Q7TSU7 RefSeq (mRNA) NM_032123 NM_199179 NM_199180 NM_001329530 NM_001363667 NM_172898 RefSeq (protein) NP_001316459 NP_115499 NP_954648 NP_954649 NP_001350596 NP_766486 Location (UCSC) Chr 19: 35.86 – 35.87 Mb Chr 7: 30.15 – 30.16 Mb PubMed search [3] [4]
Wikidata
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KIRREL2 is a member of the NEPH protein family, which includes NEPH1 (KIRREL) and NEPH2 (KIRREL3).