KLC3

Kinesin light chain 3 is a protein that in humans is encoded by the KLC3 gene.^[5]

KLC3
Identifiers
Aliases	KLC3, KLC2, KLC2L, KLCt, KNS2B, kinesin light chain 3
External IDs	OMIM: 601334; MGI: 1277971; HomoloGene: 14899; GeneCards: KLC3; OMA:KLC3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 45,333,434 bp[1] End 45,351,520 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 9.62 cM Start 19,128,362 bp[2] End 19,138,029 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of abdomen skin of leg amniotic fluid gingival epithelium superficial temporal artery skin of thigh nasal epithelium vulva external globus pallidus Top expressed in lip vestibular membrane of cochlear duct neural layer of retina esophagus skin of external ear hair follicle skin of back skin of abdomen olfactory epithelium seminiferous tubule More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding microtubule motor activity protein binding kinesin binding Cellular component cytoplasm neuron projection motile cilium microtubule cytoskeleton kinesin complex ciliary rootlet Biological process axo-dendritic transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 147700 232943 Ensembl ENSG00000104892 ENSMUSG00000040714 UniProt Q6P597 Q91W40 RefSeq (mRNA) NM_145275 NM_177417 NM_001286038 NM_001286039 NM_146182 RefSeq (protein) NP_803136 NP_001272967 NP_001272968 NP_666294 NP_001390614 Location (UCSC) Chr 19: 45.33 – 45.35 Mb Chr 7: 19.13 – 19.14 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.^[5]

Interactions

KLC3 has been shown to interact with YWHAH.^[6]