KLF13

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.^[5][6][7]

KLF13
Identifiers
Aliases	KLF13, BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1, Kruppel-like factor 13, Kruppel like factor 13
External IDs	OMIM: 605328; MGI: 1354948; HomoloGene: 32288; GeneCards: KLF13; OMA:KLF13 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q13.3 Start 31,326,835 bp[1] End 31,435,665 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 C Start 63,536,099 bp[2] End 63,588,663 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum granulocyte right lung mucosa of transverse colon right frontal lobe left lobe of thyroid gland body of pancreas right lobe of thyroid gland monocyte ganglionic eminence Top expressed in Rostral migratory stream molar thymus granulocyte blood ankle hair follicle mesenteric lymph nodes external carotid artery Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation negative regulation of erythrocyte differentiation transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51621 50794 Ensembl ENSG00000169926 ENSG00000275746 ENSMUSG00000052040 UniProt Q9Y2Y9 Q9JJZ6 RefSeq (mRNA) NM_001302461 NM_015995 NM_021366 RefSeq (protein) NP_001289390 NP_057079 NP_067341 Location (UCSC) Chr 15: 31.33 – 31.44 Mb Chr 7: 63.54 – 63.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

There is some evidence for KLF13 having a role in obesity. A methylation site, cg07814318, within the first intron of KLF13 has been associated with obesity and orexigenic processes.^[8] Ghrelin levels also positively correlated with methylation levels of cg07814318.^[8] Moreover, expression levels of KLF13 were decreased and increased in the brains of starved and obese mice, respectively.^[8]

Function

KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.^[5][9]

KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1.^[7] It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.^{[7][10][11][12][13][14][15]}

Interactions

KLF13 has been shown to interact with CREB-binding protein,^[16] Heat shock protein 47^[16] and PCAF.^[16]

See also

• Kruppel-like factors