KLHDC3

Kelch domain-containing protein 3 is a protein that in humans is encoded by the KLHDC3 gene.^[5][6]

KLHDC3
Identifiers
Aliases	KLHDC3, PEAS, dJ20C7.3, kelch domain containing 3
External IDs	OMIM: 611248; MGI: 2651568; HomoloGene: 14290; GeneCards: KLHDC3; OMA:KLHDC3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 43,014,103 bp[1] End 43,021,298 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 22.9 cM|17 C Start 46,985,476 bp[2] End 46,991,840 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis right frontal lobe prefrontal cortex cerebellar hemisphere right hemisphere of cerebellum muscle of thigh Brodmann area 9 triceps brachii muscle nucleus accumbens Top expressed in seminiferous tubule primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell right ventricle muscle of thigh yolk sac temporal muscle ankle secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin binding protein binding Cellular component cytoplasm cytosol nucleoplasm Biological process reciprocal meiotic recombination IRE1-mediated unfolded protein response meiosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116138 71765 Ensembl ENSG00000124702 ENSMUSG00000063576 UniProt Q9BQ90 Q8VEM9 RefSeq (mRNA) NM_001242872 NM_057161 NM_001163729 NM_027910 RefSeq (protein) NP_476502 NP_001157201 NP_082186 Location (UCSC) Chr 6: 43.01 – 43.02 Mb Chr 17: 46.99 – 46.99 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2 (RAG2), a protein involved in the activation of the V(D)J recombination. This gene is found to express specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasm and meiotic chromatin, which suggests that this gene may be involved in meiotic recombination.^[6]