KLK1

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene.^[5][6][7] KLK1 is a member of the peptidase S1 family.

KLK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SPJ
Identifiers
Aliases	KLK1, KLKR, Klk6, hK1, kallikrein 1
External IDs	OMIM: 147910; MGI: 102850; HomoloGene: 110727; GeneCards: KLK1; OMA:KLK1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 50,819,146 bp[1] End 50,823,787 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.74 cM Start 43,874,784 bp[2] End 43,879,042 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas mucosa of transverse colon parotid gland rectum skin of abdomen islet of Langerhans skin of leg beta cell skin of arm gonad Top expressed in submandibular gland parotid gland right kidney left colon human kidney pyloric antrum lacrimal gland crypt of lieberkuhn of small intestine duodenum islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity serine-type endopeptidase activity hydrolase activity Cellular component extracellular exosome nucleus secretory granule Biological process proteolysis regulation of systemic arterial blood pressure zymogen activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3816 16612 Ensembl ENSG00000167748 ENSMUSG00000063903 UniProt P06870 P15947 RefSeq (mRNA) NM_002257 NM_010639 NM_001320331 NM_001320332 RefSeq (protein) NP_002248 NP_001307260 NP_001307261 NP_034769 Location (UCSC) Chr 19: 50.82 – 50.82 Mb Chr 7: 43.87 – 43.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.^[8]

See also

• Kinin–kallikrein system
• Kininogen 1