KLK10

Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.^{[5][6][7][8][9]}

KLK10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SPJ
Identifiers
Aliases	KLK10, NES1, PRSSL1, kallikrein related peptidase 10
External IDs	OMIM: 602673; MGI: 1916790; HomoloGene: 26428; GeneCards: KLK10; OMA:KLK10 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 51,012,739 bp[1] End 51,020,175 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.26 cM Start 43,430,459 bp[2] End 43,434,834 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums gingival epithelium human penis mucosa of pharynx oral cavity vulva epithelium of esophagus skin of arm body of tongue skin of abdomen Top expressed in lip esophagus skin of external ear skin of back skin of abdomen cervix blastocyst embryo rectum stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity Cellular component extracellular region secretory granule Biological process cell cycle proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5655 69540 Ensembl ENSG00000129451 ENSMUSG00000030693 UniProt O43240 Q99M20 RefSeq (mRNA) NM_001077500 NM_002776 NM_145888 NM_133712 RefSeq (protein) NP_001070968 NP_002767 NP_665895 NP_598473 Location (UCSC) Chr 19: 51.01 – 51.02 Mb Chr 7: 43.43 – 43.43 Mb PubMed search [3] [4]
Wikidata
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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.^[9]