KLK11

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.^{[5][6][7][8][9]}

KLK11
Identifiers
Aliases	KLK11, PRSS20, TLSP, kallikrein related peptidase 11
External IDs	OMIM: 604434; MGI: 1929977; HomoloGene: 27048; GeneCards: KLK11; OMA:KLK11 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 51,022,216 bp[1] End 51,028,039 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 43,424,028 bp[2] End 43,428,687 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium skin of abdomen skin of arm skin of leg human penis oral cavity mucosa of pharynx vulva cervix epithelium gallbladder Top expressed in lip esophagus skin of external ear embryo skin of back embryo genital tubercle umbilical cord skin of abdomen trachea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity Cellular component extracellular region Golgi apparatus extracellular exosome extracellular space secretory granule Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11012 56538 Ensembl ENSG00000167757 ENSMUSG00000067616 UniProt Q9UBX7 Q9QYN3 RefSeq (mRNA) NM_001136032 NM_001167605 NM_006853 NM_144947 NM_001177373 NM_019974 RefSeq (protein) NP_001129504 NP_001161077 NP_006844 NP_659196 NP_001170844 NP_064358 Location (UCSC) Chr 19: 51.02 – 51.03 Mb Chr 7: 43.42 – 43.43 Mb PubMed search [3] [4]
Wikidata
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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.^[9]