KLK13

Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene.^[4][5][6]

KLK13kmpll
Identifiers
Aliases	KLK13, KLK-L4, KLKL4, kallikrein related peptidase 13
External IDs	OMIM: 605505; MGI: 3615275; HomoloGene: 56714; GeneCards: KLK13; OMA:KLK13 - orthologs
Gene location (Mouse) Chr. Chromosome 7 (mouse)[1] Band 7|7 B3 Start 43,361,991 bp[1] End 43,376,958 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in esophagus lip embryo embryo left lung lobe hair follicle zygote stomach external naris oocyte BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity endopeptidase activity serine-type endopeptidase activity protein binding hydrolase activity Cellular component cytoplasm extracellular region extracellular space secretory granule Biological process cornification proteolysis protein processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26085 626834 Ensembl n/a ENSMUSG00000054046 UniProt Q9UKR3 Q5BQ95 Q5BQ97 n/a RefSeq (mRNA) NM_015596 NM_001039042 RefSeq (protein) NP_056411 NP_001335106 NP_001335107 n/a Location (UCSC) n/a Chr 7: 43.36 – 43.38 Mb PubMed search [2] [3]
Wikidata
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Function

Kallikreins are a subgroup of serine proteases having diverse physiological functions.

As of 2022, the precise physiological functions of Kallikrein 13 remain unknown. It may play a role in the defense of the upper digestive apparatus, in extracellular matrix degradation, in tissue remodelling, and in the male reproductive organs.

This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined.^[6]

Kallikrein-13 serves as a priming protease during infection by the human coronavirus HKU1.^[7]

Many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers.