KLK15

Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.^{[5][6][7][8][9]}

KLK15
Identifiers
Aliases	KLK15, ACO, HSRNASPH, kallikrein related peptidase 15
External IDs	OMIM: 610601; MGI: 2447533; HomoloGene: 77571; GeneCards: KLK15; OMA:KLK15 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 50,825,289 bp[1] End 50,837,213 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.41 cM Start 43,583,164 bp[2] End 43,589,063 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava tendon of biceps brachii Skeletal muscle tissue of rectus abdominis cerebellar vermis parotid gland body of tongue buccal mucosa cell right ventricle pons pericardium Top expressed in lip embryo secondary oocyte primary oocyte zygote placenta spermatid genital tubercle zone of skin right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity protein binding hydrolase activity serine-type endopeptidase activity Cellular component extracellular region secretory granule Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55554 317652 Ensembl ENSG00000174562 ENSMUSG00000055193 UniProt Q9H2R5 n/a RefSeq (mRNA) NM_001277081 NM_001277082 NM_017509 NM_023006 NM_138563 NM_138564 NM_174865 RefSeq (protein) NP_001264010 NP_001264011 NP_059979 n/a Location (UCSC) Chr 19: 50.83 – 50.84 Mb Chr 7: 43.58 – 43.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms.^[9]