KLK9

Kallikrein-related peptidase 9 also known as KLK9 is an enzyme which in humans is encoded by the KLK9 gene.^[5]

KLK9
Identifiers
Aliases	KLK9, KLK-L3, KLKL3, kallikrein related peptidase 9
External IDs	OMIM: 605504; MGI: 1921082; HomoloGene: 40832; GeneCards: KLK9; OMA:KLK9 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 51,002,508 bp[1] End 51,009,634 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.26 cM Start 43,441,315 bp[2] End 43,446,181 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen mucosa of esophagus tonsil vagina right uterine tube ectocervix minor salivary glands prefrontal cortex endometrium Top expressed in esophagus lip zone of skin embryo genital tubercle stomach tail of embryo urinary bladder placenta thymus More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity Cellular component extracellular region secretory granule Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 284366 101533 Ensembl ENSG00000213022 ENSMUSG00000047884 UniProt Q9UKQ9 Q32M27 RefSeq (mRNA) NM_012315 NM_028660 RefSeq (protein) NP_036447 NP_082936 Location (UCSC) Chr 19: 51 – 51.01 Mb Chr 7: 43.44 – 43.45 Mb PubMed search [3] [4]
Wikidata
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Function

KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues.^[6][7][8] KLK9 is primarily expressed in thymus, testis, spinal cord, cerebellum, trachea, mammary gland, prostate, brain, salivary gland, ovary, and skin.^[5]

Clinical significance

KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines and is a potential prognostic marker for early-stage ovarian^[9] and breast cancer patients.^[10]