KLRC4

NKG2-F type II integral membrane protein is a protein that in humans is encoded by the KLRC4 gene.^[3][4]

KLRC4
Identifiers
Aliases	KLRC4, NKG2-F, NKG2F, killer cell lectin like receptor C4
External IDs	OMIM: 602893; GeneCards: KLRC4; OMA:KLRC4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 10,407,384 bp[1] End 10,409,757 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node gallbladder spleen corpus callosum appendix right lung rectum right uterine tube Amygdala n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 8302 n/a Ensembl ENSG00000183542 n/a UniProt O43908 n/a RefSeq (mRNA) NM_013431 n/a RefSeq (protein) NP_038459 n/a Location (UCSC) Chr 12: 10.41 – 10.41 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC4 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The 3' end of the KLRC4 transcript includes the first non-coding exon found at the 5' end of the adjacent D12S2489E gene transcript.^[4]