KLRD1

CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D, member 1 (KLRD1) is a human gene.^[5]

KLRD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B6E, 3BDW, 3CDG, 3CII
Identifiers
Aliases	KLRD1, CD94, killer cell lectin like receptor D1
External IDs	OMIM: 602894; MGI: 1196275; HomoloGene: 1705; GeneCards: KLRD1; OMA:KLRD1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 10,226,058 bp[1] End 10,329,608 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F3|6 63.42 cM Start 129,568,745 bp[2] End 129,575,738 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood spleen bone marrow lymph node bone marrow cell upper lobe of left lung testicle mononuclear cell gonad Top expressed in blood spleen mesenteric lymph nodes subcutaneous adipose tissue thymus jejunum duodenum granulocyte bone marrow submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein antigen binding MHC class Ib protein binding, via antigen binding groove protein binding transmembrane signaling receptor activity MHC class I protein complex binding carbohydrate binding Cellular component integral component of membrane receptor complex plasma membrane membrane external side of plasma membrane Biological process cell surface receptor signaling pathway innate immune response natural killer cell mediated immunity regulation of immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3824 16643 Ensembl ENSG00000134539 ENSMUSG00000030165 UniProt Q13241 O54707 RefSeq (mRNA) NM_001114396 NM_002262 NM_007334 NM_001351060 NM_001351062 NM_001351063 NM_010654 RefSeq (protein) NP_001107868 NP_002253 NP_031360 NP_001337989 NP_001337991 NP_001337992 NP_034784 Location (UCSC) Chr 12: 10.23 – 10.33 Mb Chr 6: 129.57 – 129.58 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by CD94 gene is a lectin, cluster of differentiation and a receptor that is involved in cell signaling and is expressed on the surface of natural killer cells in the innate immune system. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.

Function

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence.^[5]

Interactions

KLRD1 has been shown to interact with KLRC2.^[6][7]

See also

• Cluster of differentiation
• CD94/NKG2