KMT5A

N-lysine methyltransferase KMT5A is an enzyme that in humans is encoded by the KMT5A gene.^[5][6][7][8] The enzyme is a histone methyltransferase, SET domain-containing and lysine-specific. The enzyme transfers one methyl group to histone H4 lysine residue at position 20. S-Adenosyl methionine (SAM) is both the cofactor and the methyl group donor. The lysine residue is converted to N⁶-methyllysine residue.

Leftmost: side chain of lysine. Next: N⁶-methyllysine side chain.

KMT5A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZKK, 2BQZ, 3F9W, 3F9X, 3F9Y, 3F9Z, 4IJ8, 5HQ2
Identifiers
Aliases	KMT5A, PR-Set7, SET07, SET8, SETD8, lysine methyltransferase 5A, PR/SET07
External IDs	OMIM: 607240; MGI: 1915206; HomoloGene: 41372; GeneCards: KMT5A; OMA:KMT5A - orthologs
EC number	2.1.1.354
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 123,384,132 bp[1] End 123,409,353 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 124,577,993 bp[2] End 124,600,371 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve ventricular zone right coronary artery thoracic aorta ascending aorta Descending thoracic aorta Achilles tendon right lobe of thyroid gland body of pancreas popliteal artery Top expressed in tail of embryo genital tubercle gastrula granulocyte muscle of thigh pyloric antrum zygote lip knee joint ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-lysine N-methyltransferase activity methyltransferase activity transcription corepressor activity p53 binding protein binding transferase activity lysine N-methyltransferase activity histone-lysine N-methyltransferase activity histone methyltransferase activity (H4-K20 specific) Cellular component nucleus nucleoplasm chromosome cytosol Biological process methylation regulation of transcription, DNA-templated peptidyl-lysine monomethylation cell cycle negative regulation of transcription by RNA polymerase II negative regulation of transcription, DNA-templated cell division transcription, DNA-templated regulation of DNA damage response, signal transduction by p53 class mediator histone lysine methylation regulation of signal transduction by p53 class mediator histone H4-K20 methylation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 387893 67956 Ensembl ENSG00000183955 ENSMUSG00000049327 UniProt Q9NQR1 Q2YDW7 RefSeq (mRNA) NM_020382 NM_001324504 NM_001324505 NM_001324506 NM_001367386 NM_001367388 NM_001367389 NM_030241 NM_001310723 NM_001310725 NM_001310727 RefSeq (protein) NP_001311433 NP_001311434 NP_001311435 NP_065115 NP_001354315 NP_001354317 NP_001354318 NP_001297652 NP_001297654 NP_001297656 NP_084517 NP_001392317 NP_001392319 Location (UCSC) Chr 12: 123.38 – 123.41 Mb Chr 5: 124.58 – 124.6 Mb PubMed search [3] [4]
Wikidata
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This histone modification is often abbreviated H4K20me1:

• H4 - type of histone
• K - symbol of lysine
• 20 - position of the lysine residue modified
• me - abbreviation for methyl group
• 1 - number of methyl groups transferred