KRT86

The KRT86 gene encodes for keratin, type II cuticular Hb6 protein in humans.^[5][6][7]

KRT86
Identifiers
Aliases	KRT86, HB6, Hb1, KRTHB1, KRTHB6, MNX, hHb6, K86, keratin 86
External IDs	OMIM: 601928; MGI: 109362; HomoloGene: 1717; GeneCards: KRT86; OMA:KRT86 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 52,249,300 bp[1] End 52,309,163 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F2|15 56.9 cM Start 101,371,359 bp[2] End 101,377,867 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right coronary artery skin of arm buccal mucosa cell hair follicle ascending aorta amniotic fluid left coronary artery tibialis anterior muscle decidua Top expressed in lip granulocyte Ileal epithelium embryo entorhinal cortex lactiferous gland skin of back hair follicle skin of abdomen CA3 field More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding structural molecule activity Cellular component keratin filament extracellular exosome intermediate filament extracellular space cytosol Biological process keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3892 16679 Ensembl ENSG00000170442 ENSMUSG00000067614 UniProt O43790 P97861 RefSeq (mRNA) NM_002284 NM_001320198 NM_010667 RefSeq (protein) NP_001307127 NP_034797 Location (UCSC) Chr 12: 52.25 – 52.31 Mb Chr 15: 101.37 – 101.38 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRT81, KRT83, and KRT86, is highly related. The other, less-related subfamily includes KRT82, KRT84, and KRT85. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRT81 and KRT83, is found primarily in the hair cortex. Mutations in this gene and KRT81 have been observed in patients with a rare dominant hair disease, monilethrix.^[7]