KSR1

For the KSR1 supercomputer, see Kendall Square Research.

Kinase suppressor of Ras 1 is an enzyme that in humans is encoded by the KSR1 gene.^[5][6]

KSR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KBE, 1KBF, 2LPE
Identifiers
Aliases	KSR1, KSR, RSU2, kinase suppressor of ras 1
External IDs	OMIM: 601132; MGI: 105051; HomoloGene: 8410; GeneCards: KSR1; OMA:KSR1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 27,456,448 bp[1] End 27,626,438 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 46.74 cM Start 78,904,266 bp[2] End 79,037,233 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas sural nerve oocyte right lobe of thyroid gland canal of the cervix left lobe of thyroid gland gallbladder ectocervix left testis left ovary Top expressed in muscle of thigh temporal muscle triceps brachii muscle dentate gyrus of hippocampal formation granule cell digastric muscle medial head of gastrocnemius muscle sternocleidomastoid muscle quadriceps femoris muscle granulocyte vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein C-terminus binding protein binding ATP binding MAP-kinase scaffold activity protein kinase activity signal transducer activity mitogen-activated protein kinase kinase binding chaperone binding Hsp90 protein binding 14-3-3 protein binding Cellular component cytoplasm cytosol endoplasmic reticulum membrane membrane endoplasmic reticulum cell projection ruffle membrane plasma membrane protein-containing complex Biological process intracellular signal transduction MAPK cascade cAMP-mediated signaling protein phosphorylation Ras protein signal transduction positive regulation of MAPK cascade regulation of cell population proliferation regulation of MAP kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8844 16706 Ensembl ENSG00000141068 ENSMUSG00000018334 UniProt Q8IVT5 Q61097 RefSeq (mRNA) NM_014238 NM_001367810 NM_001394583 NM_001394584 NM_001394585 NM_013571 NM_001348207 RefSeq (protein) NP_055053 NP_001354739 NP_001335136 NP_038599 Location (UCSC) Chr 17: 27.46 – 27.63 Mb Chr 11: 78.9 – 79.04 Mb PubMed search [3] [4]
Wikidata
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