KYAT1

Kynurenine—oxoglutarate transaminase 1 is an enzyme that in humans is encoded by the CCBL1 gene.^[4][5] It is one of the Kynurenine—oxoglutarate transaminases.

KYAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W7L, 1W7M, 1W7N, 3FVS, 3FVU, 3FVX, 4WLH, 4WLJ, 4WP0
Identifiers
Aliases	KYAT1, GTK, KAT1, KATI, CCBL1, kynurenine aminotransferase 1
External IDs	OMIM: 600547; MGI: 1917516; HomoloGene: 37872; GeneCards: KYAT1; OMA:KYAT1 - orthologs
EC number	4.4.1.13
Gene location (Mouse) Chr. Chromosome 2 (mouse)[1] Band 2|2 B Start 30,075,136 bp[1] End 30,095,859 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in esophagus right kidney lip left lobe of liver human kidney middle ear Eustachian tube salivary gland seminal vesicula parotid gland BioGPS More reference expression data
Gene ontology Molecular function transferase activity kynurenine-oxoglutarate transaminase activity protein homodimerization activity L-glutamine:pyruvate aminotransferase activity transaminase activity glutamine-phenylpyruvate transaminase activity protein binding catalytic activity lyase activity L-phenylalanine:pyruvate aminotransferase activity pyridoxal phosphate binding L-glutamine aminotransferase activity cysteine-S-conjugate beta-lyase activity Cellular component nucleoplasm cytoplasm cytosol mitochondrion Biological process L-phenylalanine catabolic process cellular amino acid biosynthetic process biosynthesis L-kynurenine catabolic process tryptophan catabolic process cellular modified amino acid metabolic process kynurenine metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 883 70266 Ensembl ENSG00000171097 ENSMUSG00000039648 UniProt Q16773 Q8BTY1 RefSeq (mRNA) NM_001122671 NM_001122672 NM_001287390 NM_004059 NM_172404 NM_001356474 NM_001356475 RefSeq (protein) NP_001116143 NP_001116144 NP_001274319 NP_004050 NP_001339917 NP_001339918 NP_001339919 NP_001339920 NP_001339921 NP_001339922 NP_001339923 NP_001339924 NP_001339925 NP_001339926 NP_001339927 NP_001339928 NP_765992 NP_001343403 NP_001343404 Location (UCSC) n/a Chr 2: 30.08 – 30.1 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a cytosolic enzyme which is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism leads to the formation of reactive metabolites which can lead to nephrotoxicity and neurotoxicity.^[5]