KTN1

Kinectin is a protein that in humans is encoded by the KTN1 gene.^[5][6]

KTN1
Identifiers
Aliases	KTN1, CG1, KNT, MU-RMS-40.19, kinectin 1
External IDs	OMIM: 600381; MGI: 109153; HomoloGene: 135663; GeneCards: KTN1; OMA:KTN1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.3 Start 55,559,072 bp[1] End 55,701,526 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 47,885,905 bp[2] End 47,977,351 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm glutes Skeletal muscle tissue of rectus abdominis biceps brachii Skeletal muscle tissue of biceps brachii Epithelium of choroid plexus renal medulla mucosa of paranasal sinus epithelium of colon vastus lateralis muscle Top expressed in tail of embryo triceps brachii muscle temporal muscle sternocleidomastoid muscle genital tubercle digastric muscle epithelium of lens muscle of thigh neural layer of retina right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding kinesin binding RNA binding cadherin binding Cellular component integral component of membrane integral component of plasma membrane endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum lumen Biological process microtubule-based movement post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3895 16709 Ensembl ENSG00000126777 ENSMUSG00000021843 UniProt Q86UP2 Q61595 RefSeq (mRNA) NM_001079521 NM_001079522 NM_001271014 NM_004986 NM_182926 NM_001293635 NM_001293636 NM_008477 NM_001347519 NM_001347520 NM_001347521 NM_001347522 NM_001347523 NM_001347524 NM_001347525 NM_001347526 NM_001347527 NM_001347528 NM_001379486 NM_001379487 NM_001379488 NM_001379489 NM_001379490 NM_001379491 NM_001379492 NM_001379493 NM_001379494 NM_001379495 RefSeq (protein) NP_001072989 NP_001072990 NP_001257943 NP_004977 NP_001280564 NP_001280565 NP_001334448 NP_001334449 NP_001334450 NP_001334451 NP_001334452 NP_001334453 NP_001334454 NP_001334455 NP_001334456 NP_001334457 NP_032503 NP_001366415 NP_001366416 NP_001366417 NP_001366418 NP_001366419 NP_001366420 NP_001366421 NP_001366422 NP_001366423 NP_001366424 Location (UCSC) Chr 14: 55.56 – 55.7 Mb Chr 14: 47.89 – 47.98 Mb PubMed search [3] [4]
Wikidata
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Function

Various cellular organelles and vesicles are transported along the microtubules in the cytoplasm. Likewise, membrane recycling of the endoplasmic reticulum (ER), Golgi assembly at the microtubule organizing center, and alignment of lysosomes along microtubules are all related processes. The transport of organelles requires a special class of microtubule-associated proteins (MAPs). One of these is the molecular motor kinesin (see MIM 148760 and MIM 600025), an ATPase that moves vesicles unidirectionally toward the plus end of the microtubule. Another such MAP is kinectin, a large integral ER membrane protein. Antibodies directed against kinectin have been shown to inhibit its binding to kinesin.[supplied by OMIM]^[6]

Interactions

KTN1 has been shown to interact with EEF1D,^[7] RhoG^[8][9] and RHOA.^{[8][9][10][11]}