Kua-UEV

Ubiquitin-conjugating enzyme E2 variant 1, also known as Kua-UEV, is a human gene.^[3]

PEDS1-UBE2V1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2A4D, 2C2V, 2HLW
Identifiers
Aliases	PEDS1-UBE2V1, CROC-1B, CROC1B, KUA-UEV, Kua-UEV, TMEM189-UBE2V1 readthrough, PEDS1-UBE2V1 readthrough, TMEM189-UBE2V1
External IDs	HomoloGene: 100008; GeneCards: PEDS1-UBE2V1; OMA:PEDS1-UBE2V1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.13 Start 50,081,124 bp[1] End 50,153,637 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium placenta prefrontal cortex right coronary artery mucosa of esophagus right lung gastrocnemius muscle superior frontal gyrus ectocervix monocyte n/a More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin protein ligase binding ubiquitin protein ligase activity protein binding ubiquitin conjugating enzyme activity Cellular component cytoplasm integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum cytosol ubiquitin conjugating enzyme complex UBC13-UEV1A complex ubiquitin ligase complex extracellular exosome nucleus nucleoplasm protein-containing complex Biological process protein ubiquitination protein polyubiquitination Fc-epsilon receptor signaling pathway protein K63-linked ubiquitination nucleotide-binding oligomerization domain containing signaling pathway positive regulation of transcription, DNA-templated stimulatory C-type lectin receptor signaling pathway regulation of DNA repair regulation of transcription, DNA-templated T cell receptor signaling pathway cell differentiation postreplication repair positive regulation of I-kappaB kinase/NF-kappaB signaling JNK cascade positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 387522 n/a Ensembl ENSG00000124208 n/a UniProt Q13404 n/a RefSeq (mRNA) NM_003349 NM_199203 n/a RefSeq (protein) NP_001155977 NP_954580 NP_954673 NP_001027459 NP_001244322 NP_001244323 NP_001244324 NP_001244325 NP_001244326 NP_001244327 NP_001244328 NP_001269504 NP_001269505 NP_001269506 NP_001269507 NP_001269508 NP_001269509 NP_068823 NP_071887 NP_954595 NP_954673 n/a Location (UCSC) Chr 20: 50.08 – 50.15 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

The Kua-UEV mRNA is an infrequent but naturally occurring co-transcribed product of the neighboring Kua and UBE2V1 genes.^[4] Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. Two alternative transcripts encoding different isoforms have been described. The proteins produced by these transcripts have UEV1 B domains but the proteins are localized to the cytoplasm rather than to the nucleus. The significance of these co-transcribed mRNAs and the function of their protein products have not yet been determined.^[3]