L3MBTL

Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene.^[5][6][7]

L3MBTL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OYX, 1OZ2, 1OZ3, 2PQW, 2RHI, 2RHU, 2RHX, 2RHY, 2RHZ, 2RI2, 2RI3, 2RI5, 2RJC, 2RJD, 2RJE, 2RJF, 3OQ5, 3P8H, 3UWN
Identifiers
Aliases	L3MBTL1, H-L(3)MBT, L3MBTL, ZC2HC3, dJ138B7.3, l(3)mbt-like 1 (Drosophila), histone methyl-lysine binding protein, L3MBTL histone methyl-lysine binding protein 1
External IDs	OMIM: 608802; MGI: 2676663; HomoloGene: 41846; GeneCards: L3MBTL1; OMA:L3MBTL1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 43,489,442 bp[1] End 43,550,950 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H2 Start 162,943,472 bp[2] End 162,974,522 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum pituitary gland anterior pituitary subthalamic nucleus right uterine tube tongue right frontal lobe superior surface of tongue superior vestibular nucleus glutes Top expressed in hypothalamus zygote respiratory epithelium female urethra olfactory epithelium primary visual cortex superior frontal gyrus ureter striatum of neuraxis cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity histone binding zinc ion binding SAM domain binding chromatin binding metal ion binding methylated histone binding protein binding identical protein binding nucleosome binding Cellular component plasma membrane nucleolus chromatin condensed chromosome nucleus nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of cell cycle negative regulation of transcription, DNA-templated regulation of megakaryocyte differentiation regulation of mitotic nuclear division regulation of signal transduction by p53 class mediator chromatin organization hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26013 241764 Ensembl ENSG00000185513 ENSMUSG00000035576 UniProt Q9Y468 A2A5N8 RefSeq (mRNA) NM_032107 NM_015478 NM_001081338 RefSeq (protein) NP_056293 NP_115479 NP_001074807 Location (UCSC) Chr 20: 43.49 – 43.55 Mb Chr 2: 162.94 – 162.97 Mb PubMed search [3] [4]
Wikidata
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This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]