LAIR2

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.^[3][4]

LAIR2
Identifiers
Aliases	LAIR2, CD306, leukocyte associated immunoglobulin like receptor 2
External IDs	OMIM: 602993; HomoloGene: 88663; GeneCards: LAIR2; OMA:LAIR2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,497,879 bp[1] End 54,510,687 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte placenta blood lymph node appendix monocyte bone marrow spleen right coronary artery right lung n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component extracellular region Biological process regulation of immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3904 n/a Ensembl ENSG00000167618 ENSG00000275819 ENSG00000277335 ENSG00000274084 n/a UniProt Q6ISS4 n/a RefSeq (mRNA) NM_002288 NM_021270 n/a RefSeq (protein) NP_002279 NP_067154 n/a Location (UCSC) Chr 19: 54.5 – 54.51 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene.^[4]