LARP6

La-related protein 6 also known as acheron or La ribonucleoprotein domain family member 6 (LARP6), is a protein that in humans is encoded by the LARP6 gene.^[5]

LARP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MTF, 2MTG
Identifiers
Aliases	LARP6, ACHN, La ribonucleoprotein domain family member 6, La ribonucleoprotein 6, translational regulator
External IDs	OMIM: 611300; MGI: 1914807; HomoloGene: 32408; GeneCards: LARP6; OMA:LARP6 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q23 Start 70,829,130 bp[1] End 70,854,157 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 60,620,272 bp[2] End 60,646,084 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus inferior ganglion of vagus nerve gastric mucosa left testis lateral nuclear group of thalamus right testis C1 segment subthalamic nucleus inferior olivary nucleus pars reticulata Top expressed in pontine nuclei lateral geniculate nucleus superior colliculus anterior horn of spinal cord deep cerebellar nuclei dorsal tegmental nucleus lateral hypothalamus ventral tegmental area piriform cortex facial motor nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function RNA binding nucleic acid binding protein binding sequence-specific mRNA binding myosin binding RNA stem-loop binding mRNA 5'-UTR binding Cellular component cytoplasm nucleus polysome ribonucleoprotein complex Biological process RNA processing regulation of translation positive regulation of collagen biosynthetic process positive regulation of translation positive regulation of mRNA binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55323 67557 Ensembl ENSG00000166173 ENSMUSG00000034839 UniProt Q9BRS8 Q8BN59 RefSeq (mRNA) NM_197958 NM_001286679 NM_018357 NM_026235 RefSeq (protein) NP_001273608 NP_060827 NP_932062 NP_080511 Location (UCSC) Chr 15: 70.83 – 70.85 Mb Chr 9: 60.62 – 60.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical relevance

In a recent genome-wide association study, LARP6 gene has been associated with fasting glucose traits, type 2 diabetes and obesity.^[6]