LASP1

LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene.^[5][6]

LASP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3I35
Identifiers
Aliases	LASP1, MLN50, LIM and SH3 protein 1, LASP-1
External IDs	OMIM: 602920; MGI: 109656; HomoloGene: 4480; GeneCards: LASP1; OMA:LASP1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 38,869,859 bp[1] End 38,921,770 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 61.1 cM Start 97,689,826 bp[2] End 97,729,590 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung jejunal mucosa mucosa of ileum lactiferous duct duodenum stromal cell of endometrium superficial temporal artery trabecular bone mucosa of paranasal sinus thymus Top expressed in retinal pigment epithelium conjunctival fornix external carotid artery ciliary body internal carotid artery epithelium of stomach otic placode saccule Rostral migratory stream migratory enteric neural crest cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ion transmembrane transporter activity actin filament binding actin binding protein binding metal ion binding cadherin binding Cellular component cell cortex extracellular exosome cytoskeleton focal adhesion cortical actin cytoskeleton cytoplasm Biological process ion transmembrane transport ion transport positive regulation of signal transduction transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3927 16796 Ensembl ENSG00000002834 ENSMUSG00000038366 UniProt Q14847 Q61792 RefSeq (mRNA) NM_001271608 NM_006148 NM_010688 RefSeq (protein) NP_001258537 NP_006139 NP_034818 Location (UCSC) Chr 17: 38.87 – 38.92 Mb Chr 11: 97.69 – 97.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of a LIM protein subfamily which is characterized by a LIM motif and a domain of Src homology region 3. This protein functions as an actin-binding protein and possibly in cytoskeletal organization.^[6]

Interactions

LASP1 has been shown to interact with Zyxin.^[7]