LAT2

Linker for activation of T-cells family member 2 is a protein that in humans is encoded by the LAT2 gene.^[5][6][7]

LAT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MAZ
Identifiers
Aliases	LAT2, LAB, NTAL, WBSCR15, WBSCR5, WSCR5, HSPC046, linker for activation of T-cells family member 2, linker for activation of T cells family member 2
External IDs	OMIM: 605719; MGI: 1926479; HomoloGene: 11297; GeneCards: LAT2; OMA:LAT2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q11.23 Start 74,199,652 bp[1] End 74,229,834 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 134,628,876 bp[2] End 134,643,879 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood bone marrow spleen appendix bone marrow cells lymph node trabecular bone superficial temporal artery Top expressed in spleen granulocyte ankle joint mesenteric lymph nodes blood spermatocyte morula lip stroma of bone marrow embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding SH2 domain binding Cellular component integral component of membrane membrane raft mast cell granule plasma membrane extracellular exosome membrane intracellular anatomical structure Biological process B cell receptor signaling pathway Fc-epsilon receptor signaling pathway B cell activation immune response-regulating signaling pathway intracellular signal transduction mast cell degranulation adaptive immune response calcium-mediated signaling immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7462 56743 Ensembl ENSG00000086730 ENSMUSG00000040751 UniProt Q9GZY6 Q9JHL0 RefSeq (mRNA) NM_014146 NM_032463 NM_032464 NM_020044 NM_022964 RefSeq (protein) NP_054865 NP_115852 NP_115853 NP_064428 NP_075253 Location (UCSC) Chr 7: 74.2 – 74.23 Mb Chr 5: 134.63 – 134.64 Mb PubMed search [3] [4]
Wikidata
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This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.^[7]