LCMT2

Leucine carboxyl methyltransferase 2 is an enzyme that in humans is encoded by the LCMT2 gene.^[5][6][7]

LCMT2
Identifiers
Aliases	LCMT2, PPM2, TYW4, leucine carboxyl methyltransferase 2
External IDs	OMIM: 611246; MGI: 1353659; HomoloGene: 19642; GeneCards: LCMT2; OMA:LCMT2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.3 Start 43,323,649 bp[1] End 43,330,582 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 120,958,788 bp[2] End 120,971,134 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle germinal epithelium gingival epithelium kidney tubule glomerulus metanephric glomerulus gonad palpebral conjunctiva epithelium of nasopharynx retinal pigment epithelium Top expressed in right kidney proximal tubule otic vesicle right ventricle medullary collecting duct medial ganglionic eminence islet of Langerhans epithelium of stomach primitive streak renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity protein binding S-adenosylmethionine-dependent methyltransferase activity tRNA methyltransferase activity protein C-terminal leucine carboxyl O-methyltransferase activity Cellular component cytoplasm cytosol Biological process tRNA modification methylation tRNA methylation wybutosine biosynthetic process tRNA processing C-terminal protein methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9836 329504 Ensembl ENSG00000168806 ENSMUSG00000074890 UniProt O60294 Q8BYR1 RefSeq (mRNA) NM_014793 NM_177846 RefSeq (protein) NP_055608 NP_808514 Location (UCSC) Chr 15: 43.32 – 43.33 Mb Chr 2: 120.96 – 120.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this intronless gene belongs to the methyltransferase superfamily and acts as a G₁/S and G₂/M phase checkpoint regulator. It has been hypothesized that cigarette smoke-induced oxidative stress and transforming growth factor beta 1 may inhibit cellular proliferation by modulating the expression of this protein.^[7]