LCOR

Ligand-dependent corepressor is a protein that in humans is encoded by the LCOR gene.^[5][6][7]

LCOR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2COB
Identifiers
Aliases	LCOR, MLR2, ligand dependent nuclear receptor corepressor, C10orf12
External IDs	OMIM: 607698; MGI: 2443930; HomoloGene: 22914; GeneCards: LCOR; OMA:LCOR - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.1 Start 96,832,254 bp[1] End 96,995,956 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 41,471,076 bp[2] End 41,574,975 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte jejunal mucosa mucosa of paranasal sinus mucosa of ileum visceral pleura cardia pylorus renal medulla nipple mucosa of sigmoid colon Top expressed in epithelium of stomach ventromedial nucleus migratory enteric neural crest cell Rostral migratory stream ciliary body lateral septal nucleus mammillary body human fetus retinal pigment epithelium left colon More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity transcription factor binding Cellular component nucleus nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84458 212391 Ensembl ENSG00000196233 ENSMUSG00000025019 UniProt Q96JN0 Q6ZPI3 RefSeq (mRNA) NM_001170765 NM_001170766 NM_001346516 NM_015652 NM_032440 NM_172154 NM_001370767 RefSeq (protein) NP_001164236 NP_001164237 NP_001333445 NP_115816 NP_742166 NP_001357696 Location (UCSC) Chr 10: 96.83 – 97 Mb Chr 19: 41.47 – 41.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.^[7]