LCORL

Ligand dependent nuclear receptor corepressor like is a protein that in humans is encoded by the LCORL gene. ^[5]

LCORL
Identifiers
Aliases	LCORL, MLR1, ligand dependent nuclear receptor corepressor like
External IDs	OMIM: 611799; MGI: 2651932; HomoloGene: 82325; GeneCards: LCORL; OMA:LCORL - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.31 Start 17,841,199 bp[1] End 18,021,876 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B3 Start 45,697,181 bp[2] End 45,857,615 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell endothelial cell sperm jejunal mucosa visceral pleura mucosa of ileum tibia parietal pleura pancreatic ductal cell ventricular zone Top expressed in ventromedial nucleus habenula Rostral migratory stream spermatocyte barrel cortex lumbar spinal ganglion anterior amygdaloid area lateral septal nucleus pineal gland epithelium of small intestine More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 254251 209707 Ensembl ENSG00000178177 ENSMUSG00000015882 UniProt Q8N3X6 Q3U285 RefSeq (mRNA) NM_001166139 NM_153686 NM_001163073 NM_172153 NM_178142 NM_001359871 NM_001359872 NM_001359873 NM_001359874 RefSeq (protein) NP_001159611 NP_710153 NP_001352587 NP_001352588 NP_001352589 NP_001352590 NP_001352591 NP_001352592 NP_001352594 NP_001156545 NP_742165 NP_835278 NP_001346800 NP_001346801 NP_001346802 NP_001346803 Location (UCSC) Chr 4: 17.84 – 18.02 Mb Chr 5: 45.7 – 45.86 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants.