LCP1

Plastin-2 is a protein that in humans is encoded by the LCP1 gene.^[5]

LCP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D85
Identifiers
Aliases	LCP1, CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2, lymphocyte cytosolic protein 1
External IDs	OMIM: 153430; MGI: 104808; HomoloGene: 80174; GeneCards: LCP1; OMA:LCP1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.13 Start 46,125,920 bp[1] End 46,211,871 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D3|14 39.63 cM Start 75,368,541 bp[2] End 75,468,282 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood bone marrow cells spleen appendix corpus epididymis trabecular bone gallbladder right lung Top expressed in granulocyte spleen tibiofemoral joint mesenteric lymph nodes thymus stroma of bone marrow yolk sac parotid gland blood seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding actin filament binding identical protein binding GTPase binding actin binding integrin binding Cellular component cytoplasm cytosol cell projection membrane focal adhesion filopodium ruffle plasma membrane stress fiber ruffle membrane actin filament actin cytoskeleton actin filament bundle podosome phagocytic cup extracellular exosome cytoskeleton extracellular space cell junction perinuclear region of cytoplasm Biological process extracellular matrix disassembly positive regulation of podosome assembly actin filament bundle assembly regulation of intracellular protein transport animal organ regeneration protein kinase A signaling cell migration wound healing, spreading of cells T cell activation involved in immune response actin filament network formation actin crosslink formation interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3936 18826 Ensembl ENSG00000136167 ENSMUSG00000021998 UniProt P13796 Q61233 RefSeq (mRNA) NM_002298 NM_001247984 NM_008879 RefSeq (protein) NP_002289 NP_002289.2 NP_001234913 NP_032905 Location (UCSC) Chr 13: 46.13 – 46.21 Mb Chr 14: 75.37 – 75.47 Mb PubMed search [3] [4]
Wikidata
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Function

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.^[6]