LEO1

RNA polymerase-associated protein LEO1 is an enzyme that in humans is encoded by the LEO1 gene.^[5][6]

LEO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4M6T
Identifiers
Aliases	LEO1, RDL, LEO1 homolog, Paf1/RNA polymerase II complex component
External IDs	OMIM: 610507; MGI: 2685031; HomoloGene: 133895; GeneCards: LEO1; OMA:LEO1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 51,938,025 bp[1] End 51,971,778 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 D Start 75,348,806 bp[2] End 75,373,714 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii ventricular zone mucosa of transverse colon ganglionic eminence oocyte rectum islet of Langerhans Achilles tendon internal globus pallidus secondary oocyte Top expressed in otic vesicle tail of embryo genital tubercle neural layer of retina zygote morula hand blastocyst embryo ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II C-terminal domain phosphoserine binding protein binding Cellular component nucleus centrosome Cdc73/Paf1 complex nucleoplasm fibrillar center Biological process negative regulation of myeloid cell differentiation positive regulation of mRNA 3'-end processing mRNA polyadenylation endodermal cell fate commitment Wnt signaling pathway histone H2B ubiquitination stem cell population maintenance regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription, DNA-templated histone monoubiquitination positive regulation of transcription elongation from RNA polymerase II promoter histone modification beta-catenin-TCF complex assembly transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 123169 235497 Ensembl ENSG00000166477 ENSMUSG00000042487 UniProt Q8WVC0 Q5XJE5 RefSeq (mRNA) NM_001286430 NM_138792 NM_001323903 NM_001323904 NM_001006122 NM_001039522 RefSeq (protein) NP_001273359 NP_001310832 NP_001310833 NP_620147 NP_001034611 Location (UCSC) Chr 15: 51.94 – 51.97 Mb Chr 9: 75.35 – 75.37 Mb PubMed search [3] [4]
Wikidata
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