LEPREL2

Prolyl 3-hydroxylase 3 is an enzyme that in humans is encoded by the LEPREL2 gene.^[5][6]

P3H3
Identifiers
Aliases	P3H3, GRCB, HSU47926, LEPREL2, prolyl 3-hydroxylase 3
External IDs	OMIM: 610342; MGI: 1315208; HomoloGene: 8401; GeneCards: P3H3; OMA:P3H3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,828,407 bp[1] End 6,839,847 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F2|6 59.17 cM Start 124,841,089 bp[2] End 124,857,752 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium anterior pituitary right hemisphere of cerebellum body of uterus apex of heart right ovary ascending aorta Descending thoracic aorta left ovary canal of the cervix Top expressed in calvaria saccule external carotid artery ascending aorta aortic valve internal carotid artery vas deferens dermis neural layer of retina fossa More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen L-ascorbic acid binding dioxygenase activity iron ion binding oxidoreductase activity metal ion binding procollagen-proline 3-dioxygenase activity Cellular component endoplasmic reticulum catalytic complex Biological process negative regulation of cell population proliferation peptidyl-proline hydroxylation collagen metabolic process peptidyl-lysine hydroxylation collagen biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10536 14789 Ensembl ENSG00000110811 ENSMUSG00000023191 UniProt Q8IVL6 Q8CG70 RefSeq (mRNA) NM_014262 NM_013534 RefSeq (protein) NP_055077 NP_038562 Location (UCSC) Chr 12: 6.83 – 6.84 Mb Chr 6: 124.84 – 124.86 Mb PubMed search [3] [4]
Wikidata
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