LHX3

LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.^[5][6][7]

LHX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JTN, 2RGT
Identifiers
Aliases	LHX3, CPHD3, LIM3, M2-LIM homeobox 3
External IDs	OMIM: 600577; MGI: 102673; HomoloGene: 7814; GeneCards: LHX3; OMA:LHX3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 136,196,250 bp[1] End 136,205,128 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 18.44 cM Start 26,090,224 bp[2] End 26,098,301 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary pancreatic ductal cell tibialis anterior muscle popliteal artery testicle Epithelium of choroid plexus optic nerve islet of Langerhans nucleus of brain Top expressed in Rathke's pouch pituitary gland pars intermedia vestibular sensory epithelium pineal gland pars distalis of adenohypophysis embryo neural layer of retina utricle pretectal area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component transcription regulator complex intracellular anatomical structure nucleus Biological process ventral spinal cord interneuron specification cell differentiation pituitary gland development regulation of transcription, DNA-templated spinal cord association neuron differentiation spinal cord motor neuron cell fate specification placenta development lung development negative regulation of apoptotic process transcription, DNA-templated positive regulation of transcription, DNA-templated animal organ morphogenesis inner ear development medial motor column neuron differentiation motor neuron axon guidance dorsal/ventral pattern formation transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8022 16871 Ensembl ENSG00000107187 ENSMUSG00000026934 UniProt Q9UBR4 P50481 RefSeq (mRNA) NM_014564 NM_178138 NM_001363746 NM_001039653 NM_010711 RefSeq (protein) NP_055379 NP_835258 NP_001350675 NP_001034742 NP_034841 Location (UCSC) Chr 9: 136.2 – 136.21 Mb Chr 2: 26.09 – 26.1 Mb PubMed search [3] [4]
Wikidata
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Function

LHX3 encodes a protein of a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.^[7]

Clinical significance

Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine.^[7]

Interactions

LHX3 has been shown to interact with Ldb1.^[8]