LIMA1

LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene.^[5][6][7][8]

LIMA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D8Y
Identifiers
Aliases	LIMA1, EPLIN, SREBP3, LIM domain and actin binding 1, LDLCQ8
External IDs	OMIM: 608364; MGI: 1920992; HomoloGene: 9484; GeneCards: LIMA1; OMA:LIMA1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 50,175,788 bp[1] End 50,283,546 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F1|15 56.13 cM Start 99,676,351 bp[2] End 99,773,337 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte tendon of biceps brachii Achilles tendon rectum mucosa of colon mucosa of sigmoid colon subcutaneous adipose tissue jejunal mucosa gastric mucosa Top expressed in genital tubercle lacrimal gland transitional epithelium of urinary bladder Rostral migratory stream left colon epithelium of stomach lobe of prostate duodenum pyloric antrum corneal stroma More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin filament binding actin binding actin monomer binding protein binding metal ion binding cadherin binding Cellular component cell junction cleavage furrow cytoskeleton brush border stress fiber focal adhesion actin cytoskeleton cytoplasm Biological process negative regulation of actin filament depolymerization ruffle organization actin filament bundle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51474 65970 Ensembl ENSG00000050405 ENSMUSG00000023022 UniProt Q9UHB6 Q9ERG0 RefSeq (mRNA) NM_001113546 NM_001113547 NM_001243775 NM_016357 NM_001113545 NM_023063 RefSeq (protein) NP_001107018 NP_001107019 NP_001230704 NP_057441 NP_001107017 NP_075550 Location (UCSC) Chr 12: 50.18 – 50.28 Mb Chr 15: 99.68 – 99.77 Mb PubMed search [3] [4]
Wikidata
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EPLIN is a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles (Maul et al., 2003).[supplied by OMIM]^[8]