LIME1

Lck-interacting transmembrane adapter 1 is a protein that in humans is encoded by the LIME1 gene.^[4][5]

LIME1
Identifiers
Aliases	LIME1, LIME, LP8067, dJ583P15.4, Lck interacting transmembrane adaptor 1
External IDs	OMIM: 609809; MGI: 1919949; HomoloGene: 56785; GeneCards: LIME1; OMA:LIME1 - orthologs
Gene location (Mouse) Chr. Chromosome 2 (mouse)[1] Band 2|2 H4 Start 181,021,871 bp[1] End 181,025,421 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver blood spleen putamen bone marrow cell kidney caudate nucleus nucleus accumbens pituitary gland hippocampus proper Top expressed in granulocyte islet of Langerhans spleen bone marrow cerebellar cortex thymus hypothalamus striatum of neuraxis olfactory bulb superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase binding Cellular component integral component of membrane plasma membrane membrane extracellular space U2-type post-mRNA release spliceosomal complex B cell receptor complex Biological process B cell receptor signaling pathway T cell receptor signaling pathway adaptive immune response immune system process spliceosomal complex disassembly regulation of transcription by RNA polymerase II regulation of phosphatidylinositol 3-kinase signaling regulation of I-kappaB kinase/NF-kappaB signaling regulation of MAP kinase activity regulation of release of sequestered calcium ion into cytosol regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54923 72699 Ensembl n/a ENSMUSG00000090077 UniProt Q9H400 Q9EQR5 RefSeq (mRNA) NM_017806 NM_001305654 NM_001305655 NM_023684 RefSeq (protein) NP_001292583 NP_001292584 NP_060276 NP_076173 Location (UCSC) n/a Chr 2: 181.02 – 181.03 Mb PubMed search [2] [3]
Wikidata
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LIME1 is a raft-associated transmembrane adaptor phosphoprotein that is preferentially expressed in hemopoietic cells, particularly T cells.^[6][5]