LIMK1

LIM domain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene.^[5][6]

LIMK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3S95, 5L6W, 5HVK, 5HVJ
Identifiers
Aliases	LIMK1, LIMK, LIMK-1, LIM domain kinase 1
External IDs	OMIM: 601329; MGI: 104572; HomoloGene: 1738; GeneCards: LIMK1; OMA:LIMK1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q11.23 Start 74,082,933 bp[1] End 74,122,525 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 74.73 cM|5 G2 Start 134,684,893 bp[2] End 134,717,452 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right frontal lobe cingulate gyrus anterior cingulate cortex prefrontal cortex amygdala Brodmann area 9 granulocyte ganglionic eminence monocyte Top expressed in motor neuron gastrula internal carotid artery decidua substantia nigra external carotid artery pontine nuclei medial vestibular nucleus anterior horn of spinal cord supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding heat shock protein binding metal ion binding kinase activity protein binding protein heterodimerization activity ATP binding protein kinase activity protein serine/threonine kinase activity signal transducer activity Cellular component membrane focal adhesion cytoplasm nucleus Golgi apparatus cytosol nuclear speck neuron projection lamellipodium cell projection Biological process Fc-gamma receptor signaling pathway involved in phagocytosis phosphorylation nervous system development negative regulation of ubiquitin-protein transferase activity Rho protein signal transduction positive regulation of actin filament bundle assembly actin cytoskeleton organization signal transduction positive regulation of axon extension protein phosphorylation positive regulation of stress fiber assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3984 16885 Ensembl ENSG00000106683 ENSMUSG00000029674 UniProt P53667 P53668 RefSeq (mRNA) NM_016735 NM_001204426 NM_002314 NM_010717 NM_001305875 RefSeq (protein) NP_001191355 NP_002305 NP_001292804 NP_034847 Location (UCSC) Chr 7: 74.08 – 74.12 Mb Chr 5: 134.68 – 134.72 Mb PubMed search [3] [4]
Wikidata
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Function

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development.^[7]

Clinical significance

LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.^[7]

Interactions

LIMK1 has been shown to interact with:

• CFL1,^[8][9]
• CDKN1C,^[10]
• NRG1,^[11]
• PAK1,^[12]
• PAK4,^[13] and
• YWHAZ.^[14]