LIMK2

LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.^[5][6][7]

LIMK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X6A, 4TPT
Identifiers
Aliases	LIMK2, LIM domain kinase 2
External IDs	OMIM: 601988; MGI: 1197517; HomoloGene: 55911; GeneCards: LIMK2; OMA:LIMK2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 31,212,239 bp[1] End 31,280,080 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 3,294,256 bp[2] End 3,359,189 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium blood skin of abdomen skin of leg hair follicle right uterine tube palpebral conjunctiva minor salivary glands olfactory zone of nasal mucosa mucosa of transverse colon Top expressed in lip corneal stroma gastrula neural layer of retina decidua dentate gyrus of hippocampal formation granule cell superior frontal gyrus esophagus yolk sac granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine kinase activity ATP binding protein binding protein heterodimerization activity nucleotide binding kinase activity metal ion binding protein kinase activity transferase activity signal transducer activity Cellular component nucleus cytoplasm cis-Golgi network Biological process protein phosphorylation spermatogenesis phosphorylation intracellular signal transduction head development cornea development in camera-type eye actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3985 16886 Ensembl ENSG00000182541 ENSMUSG00000020451 UniProt P53671 O54785 RefSeq (mRNA) NM_016733 NM_001031801 NM_005569 NM_001034030 NM_010718 NM_173053 NM_001361623 RefSeq (protein) NP_001026971 NP_005560 NP_057952 NP_001029202 NP_034848 NP_774958 NP_001348552 NP_001389789 NP_001389790 NP_001389791 NP_001389792 NP_001389793 Location (UCSC) Chr 22: 31.21 – 31.28 Mb Chr 11: 3.29 – 3.36 Mb PubMed search [3] [4]
Wikidata
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Function

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.^[7]