LIMS1

LIM and senescent cell antigen-like-containing domain protein 1 is a protein that in humans is encoded by the LIMS1 gene.^[5][6][7]

LIMS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G47, 1NYP, 1U5S, 2COR, 2D8X, 2KBX, 3F6Q, 4HI8, 4HI9
Identifiers
Aliases	LIMS1, PINCH, PINCH-1, PINCH1, LIM zinc finger domain containing 1
External IDs	OMIM: 602567; MGI: 1195263; HomoloGene: 68428; GeneCards: LIMS1; OMA:LIMS1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.3 Start 108,534,355 bp[1] End 108,687,246 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B4|10 29.31 cM Start 58,159,288 bp[2] End 58,260,513 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte stromal cell of endometrium gastrocnemius muscle ascending aorta muscle of thigh decidua tail of epididymis Descending thoracic aorta epithelium of colon Skeletal muscle tissue of biceps brachii Top expressed in granulocyte left lung lobe genital tubercle cardiac muscle tissue of left ventricle sciatic nerve soleus muscle atrioventricular valve corneal stroma atrium tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding protein binding protein kinase binding zinc ion binding Cellular component cytosol membrane cell-cell junction focal adhesion plasma membrane cell junction perinuclear region of cytoplasm protein-containing complex cytoplasm Biological process cellular response to transforming growth factor beta stimulus establishment of protein localization positive regulation of GTPase activity positive regulation of substrate adhesion-dependent cell spreading positive regulation of gene expression epithelial to mesenchymal transition positive regulation of focal adhesion assembly regulation of epithelial cell proliferation negative regulation of transcription, DNA-templated cell junction assembly positive regulation of cell-substrate adhesion tumor necrosis factor-mediated signaling pathway protein heterooligomerization positive regulation of NIK/NF-kappaB signaling cell-cell junction organization cell-cell adhesion positive regulation of integrin-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3987 110829 Ensembl ENSG00000169756 ENSMUSG00000019920 UniProt P48059 Q99JW4 RefSeq (mRNA) NM_001193482 NM_001193483 NM_001193484 NM_001193485 NM_001193488 NM_004987 NM_001193303 NM_026148 NM_201242 NM_001346676 NM_001359115 NM_001359116 RefSeq (protein) NP_001180411 NP_001180412 NP_001180413 NP_001180414 NP_001180417 NP_004978 NP_001358423 NP_001358424 NP_001358425 NP_001358426 NP_001358427 NP_001358428 NP_001358429 NP_001180232 NP_001333605 NP_080424 NP_957694 NP_001346044 NP_001346045 Location (UCSC) Chr 2: 108.53 – 108.69 Mb Chr 10: 58.16 – 58.26 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading.^[7]

Interactions

LIMS1 has been shown to interact with Integrin-linked kinase^[6][8] and NCK2.^[6][9]