LIMS2

LIM zinc finger domain containing 2 is a protein that in humans is encoded by the LIMS2 gene. ^[5]

LIMS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IXE
Identifiers
Aliases	LIMS2, PINCH-2, PINCH2, LGMD2W, LIM zinc finger domain containing 2, MDRCMTT
External IDs	OMIM: 607908; MGI: 2385067; HomoloGene: 41214; GeneCards: LIMS2; OMA:LIMS2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.3 Start 127,638,381 bp[1] End 127,681,786 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 32,055,343 bp[2] End 32,091,672 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle layer of sigmoid colon body of uterus right coronary artery popliteal artery tibial arteries ascending aorta Descending thoracic aorta left coronary artery right lung Top expressed in tunica media of zone of aorta interventricular septum ascending aorta right lung lobe sciatic nerve left lobe of liver umbilical cord spermatocyte aortic valve myocardium of ventricle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding Cellular component cytosol cell junction plasma membrane membrane nucleus focal adhesion cytoplasm cell-cell junction Biological process positive regulation of integrin-mediated signaling pathway negative regulation of neural precursor cell proliferation cell-cell junction organization negative regulation of apoptotic process negative regulation of hepatocyte proliferation cell junction assembly negative regulation of epithelial cell proliferation cell-cell adhesion positive regulation of substrate adhesion-dependent cell spreading Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55679 225341 Ensembl ENSG00000072163 ENSMUSG00000024395 UniProt Q7Z4I7 Q91XD2 RefSeq (mRNA) NM_001136037 NM_001161403 NM_001161404 NM_001256542 NM_017980 NM_144862 NM_001365015 NM_001379137 NM_001379138 RefSeq (protein) NP_001129509 NP_001154875 NP_001154876 NP_001243471 NP_060450 NP_659111 NP_001351944 NP_001366066 NP_001366067 Location (UCSC) Chr 2: 127.64 – 127.68 Mb Chr 18: 32.06 – 32.09 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].