LIN7A

Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene.^[5][6][7]

LIN7A
Identifiers
Aliases	LIN7A, LIN-7A, LIN7, MALS-1, TIP-33, VELI1, lin-7 homolog A, crumbs cell polarity complex component, MALS1
External IDs	OMIM: 603380; MGI: 2135609; HomoloGene: 20976; GeneCards: LIN7A; OMA:LIN7A - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.31 Start 80,792,520 bp[1] End 80,937,934 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D1 Start 107,107,547 bp[2] End 107,257,335 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell middle temporal gyrus retinal pigment epithelium primary visual cortex trabecular bone blood cerebellar cortex cerebellar hemisphere entorhinal cortex Top expressed in lobe of cerebellum seminiferous tubule cerebellar vermis lateral septal nucleus lumbar spinal ganglion nucleus accumbens neural layer of retina primary motor cortex inferior colliculi superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding L27 domain binding Cellular component postsynaptic membrane membrane postsynaptic density cell-cell junction bicellular tight junction plasma membrane cell junction basolateral plasma membrane neuron projection extracellular exosome presynapse synapse MPP7-DLG1-LIN7 complex intracellular anatomical structure Biological process protein localization to basolateral plasma membrane maintenance of epithelial cell apical/basal polarity protein transport synaptic vesicle transport inner ear development neurotransmitter secretion exocytosis transport protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8825 108030 Ensembl ENSG00000111052 ENSMUSG00000019906 UniProt O14910 Q8JZS0 RefSeq (mRNA) NM_004664 NM_001324423 NM_001033223 NM_001039354 NM_001284329 RefSeq (protein) NP_001311352 NP_004655 NP_001028395 NP_001034443 NP_001271258 Location (UCSC) Chr 12: 80.79 – 80.94 Mb Chr 10: 107.11 – 107.26 Mb PubMed search [3] [4]
Wikidata
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Interactions

LIN7A has been shown to interact with:

• CASK,^[8][9]
• DLG1,^[8] and
• KCNJ12.^[8][10]