LMLN

Leishmanolysin-like (metallopeptidase M8 family) is a protein that in humans is encoded by the LMLN gene.^[5]

LMLN
Identifiers
Aliases	LMLN, GP63, INV, IX14, MSP, leishmanolysin like peptidase, LMNL1
External IDs	OMIM: 609380; MGI: 2444736; HomoloGene: 13198; GeneCards: LMLN; OMA:LMLN - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q29 Start 197,960,200 bp[1] End 198,043,720 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 32,882,891 bp[2] End 32,948,065 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell corpus epididymis secondary oocyte caput epididymis mucosa of paranasal sinus Brodmann area 23 tail of epididymis pancreatic ductal cell sperm middle temporal gyrus Top expressed in otolith organ utricle neural layer of retina substantia nigra spermatocyte trigeminal ganglion Rostral migratory stream ventromedial nucleus cumulus cell retinal pigment epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity metalloendopeptidase activity hydrolase activity metallopeptidase activity metal ion binding Cellular component lipid droplet membrane focal adhesion cytoplasm cytosol Biological process cell cycle cell adhesion proteolysis cell division Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89782 239833 Ensembl ENSG00000185621 ENSMUSG00000022802 UniProt Q96KR4 Q8BMN4 RefSeq (mRNA) NM_001136049 NM_033029 NM_172823 RefSeq (protein) NP_001129521 NP_149018 NP_766411 Location (UCSC) Chr 3: 197.96 – 198.04 Mb Chr 16: 32.88 – 32.95 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009].